Discussion
Coronavirus disease 2019
(COVID-19),
which was identified due to the case of viral pneumonia in 2019, and was
named by the world health organization on January 12,
2020[1].Coronavirus is a large family of viruses
known to cause serious illnesses such as MERS and
SARS[5].The novel coronavirus is a new strain of
coronavirus that has never been found in humans before.Since December
2019, A lot of viral pneumonia cases have been detected, which have been
diagnosed as viral pneumonia infection.People infected with coronavirus
after the common signs of respiratory symptoms, fever, cough, gas and
breathing difficulties.In more severe cases, the infection can lead to
pneumonia, severe acute respiratory syndrome, kidney failure, and even
death[6, 7].There is no specific treatment for
diseases caused by novel coronaviruses
currently[8]. The generally susceptible and high
mortality associated with COVID-19 led us to conduct this systematic
review and meta-analysis to summarize the available options for
treatment of novel coronavirus infection based on previous reports of
therapy of SARS,MERS.
Convalescent
plasma plays an important role in the treatment of SARS and MERS for
severe respiratory infections[9].Cheng
[10]found that convalescent plasma therapy had
benefits effect for SARS,especialy in the early phase.
Soo[11]Conformed that Patients with convalescent
plasma therapy had a shorter hospital stay, lower mortality and no
immediate adverse effects were observed. Yeh[12]made a conclusion that infected SARS in Taiwan hospital whose condition
had progressed severely survived after transfusion with convalescent
plasma. Chun [13]reported Transfusion-Related
Acute Lung Injury occured afer Convalescent Plasma Transfusion in a
Patient With Middle East Respiratory Syndrome. Jae-Hoon
Ko[14] reported donor convalescent plasma with a
neutralization activity of a PRNT titer 1:80 should be used in MERS.
This study revealed that the therapy of Convalescent plasma can reduce
mortality of patients with Coronavirus.The study provided a high sample
size and the conclusions drawn by the study are highly credible because
of the comprehensive data collection strategy. However,there were
several limitations to this study. The distribution of studies between
locations was not uniform. we were able to find and extract data for the
meta-analysis from Hong Kong, Taiwan, Korea. In additional , most of the
selected studies were from hospital and no strict control group. There
was no convalescent plasma for the treatment of patients with
Coronavirus in the early stages. there may be reporting bias in some
details. Moreover,The systematic review is likely to have publication
bias as some articals used other languages .Therefore, the conclusions
of this Meta-analysis still need to be verified by further studies to
clarify the associations.
We hope this study will provide important information for policy-makers
pay more attention to The effectiveness of convalescent plasma for the
treatment of patients with Coronavirus , Improve survival of critically
ill patients[15].
Acknowledgements: The authors declare no conflict of interest in this
study.
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