GRADE framework adherence
We describe the use of the GRADE framework in the included CPGs. GRADE can be used to define the CPG questions, develop SR, identify the importance of the outcomes, prepare evidence profile, summary of findings (SoF), assess the overall quality of the evidence and decide on the direction and strength of the recommendation. Currently, there is not a validated tool to assess adherence to GRADE. We defined an appropriate use of GRADE framework if the CPGs reported the following items: (7-10)