Predicting Pacific Decadal Oscillation (PDO) transitions and understanding the associated mechanisms has proven a critical but challenging task in climate science. As a form of decadal variability, the PDO is associated with both large-scale climate shifts and regional climate predictability. We show that artificial neural networks (ANNs) predict PDO persistence and transitions from 12 months onward. Using layer-wise relevance propagation to investigate the ANN predictions, we demonstrate that the ANNs utilize oceanic patterns that have been previously linked to predictable PDO behavior. For PDO transitions, ANNs recognize a build-up of ocean heat content in the off-equatorial western Pacific 12-27 months before a transition occurs. The results support the continued use of ANNs in climate studies where explainability tools can assist in mechanistic understanding of the climate system.